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MTHFR: Anxiety and Depression Solutions - With a Patient Example

Updated: Sep 9, 2019

In the first article of this series we talked about some important things you need to know when dealing with the genetic variant MTHFR including how you can have side effects from taking too much methylated folate and B12.


I also talked about how focusing on just the MTHFR variant fails to take into account the whole picture of your health.


There are many other methylation genes at work in your body and its important not to forget about the interplay between your diet, lifestyle, and environment. Specific environmental factors can also activate and deactivate the function of genes.


Let's now look at these principles in practice with an example patient.


Sunny Horizon. text overlay saying MTHFR gene: Functional medicine solutions.


The Conventional Approach to MTHFR


Sarah* is a 38 year old female who is has chronic anxiety, depression, fatigue and is starting to have pain all over her body. She has gone to her family doctor a few times and has received some routine testing which shows everything in a normal range.


Her family doctor is now suspecting a diagnosis of fibromyalgia. Her doctor orders a MTHFR genetic test and finds out she is heterozygous for both C677T and A1298C.


Sarah starts taking 5 mg of 5MTHF and 2,000mcg of methyl-B12. Almost immediately she feels awful - her anxiety drastically increases and her fatigue worsens because she can no longer sleep for more than 2 hours at a time. She jolts awake and her body feels like it is buzzing with a nervous energy.


She tells her doctor about her symptoms and he tells her to try to relax more and suggests a xanax prescription.


Not wanting to take additional pharmaceuticals if she can help it, Sarah begins to investigate natural methods to reduce anxiety and depression.


She comes across my name and reads about functional medicine and how it can offer solution to symptoms and conditions that are considered 'lifelong' and without any real treatment options.


The Functional Medicine Approach to MTHFR


Sarah comes to her new patient appointment with all of her previous blood work and genetic tests for me to look over. First, I ordered a more complete genetic test. The testing we arrange is more comprehensive and often much cheaper than genetic tests run at a hospital.


This comprehensive genetic test evaluates many genes, including COMT (involved in estrogen metabolism and detoxification, and MAO (involved in neurotransmitter metabolism) both of which she has.


Genetics and Anxiety


The presence of these two genetic variants predisposes her to have problems with metabolizing neurotransmitters like serotonin, dopamine, adrenaline, and noradrenaline.


This partially explains her anxiety. When she gets anxious her adrenaline is very high, she cannot adequately metabolize it fast enough which causes the adrenaline to stay in her system for longer than normal. This results in her to be even more anxious for longer periods of time.


Glutathione and Detoxification


We also found genetic variants associated with glutathione production - which is the body's best way of detoxing.


In addition to the comprehensive genetic testing, we checked for heavy metal toxicity and found that she had much higher than normal levels of mercury and aluminum in her body.

a polluted city
Air pollution can strain the function of certain genes

We determined most of her mercury load was transferred in-utero from her mother and some from mercury fillings that were incorrectly removed.


Aluminum was leeching into her sparkling water (from soda cans), and was in high amounts in her anti-perspirant deodorant - removing these sources resulting in her aluminum levels decline over the course of a few months with the help of a few chelating supplements.


Mercury and aluminum can go into the brain and disrupt neurotransmitter integrity and balance. Those with COMT genetic variants often have a more difficult time detoxifying from mercury. Mercury also impairs the function this gene.


Read more about Toxicity


What Causes 'Bad Genes' to Affect Health?


Sarah had these genes her whole life - so why did her symptoms start in her late 20s and early 30s?


Years of severe stress, poor diet, environmental toxins and not enough sleep strained her body to the point that it could no longer 'keep up' with the demands being made on it.